Phraeng Sanphasat used to be the main entrance to one of the three royal palaces that stood in this area. The palace entrance is marked by an arching brick gate in European style. At the top of the gate is a statuette of a torch-bearing Greek goddess. This gate was restored by the Fine Arts Department in 1976 and is all that remains of the palace.

Rama V planned this neighborhood shortly after his return from a trip to Europe in 1887. The lane had a noticeable European feel to it and many influential Siamese built large fancy homes along this street. The most famous resident of Sanphasat Road was Phibul Songkran, one of the two leaders of the 1932 coup that brought democracy to Siam.